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KMID : 0379520030190040297
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한국독성학회지
2003 Volume.19 No. 4 p.297 ~ p.301
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Biomarker-Based Exposure to Phthalates and Related Factors with Demographics
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Koo Jung-Wan
Lee Kang-Sook
Park Chung-Yill
Koo Hyun-Jung
Lee Byung-Mu
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Abstract
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To investigate biomarker-based exposure to phthalates and related factors with demographics, 100 subjects who had participated in comprehensive health check-up were selected. We collected demographics through questionnaires and analyzed urine samples for 5 phthalates. Statistical likelihoods and regression methods were applied for data analysis using censored data. The highest levels of urine phthalates were 216mutextrm{g}/ml in di-isodecyl phthalate, 29.0mutextrm{g}/ml in di-butyl phthalate, 5.78mutextrm{g}/ml in di-(2-ethylhexyl) phthalate. The median values of di-(2-ethylhexyl) phthalate were 0.2340 mutextrm{g}/ml for male smokers, 0.0399 mutextrm{g}/ml for male non-smokers and 0.0085 mutextrm{g}/ml for female non-smokers, respectively. Di-(2-ethylhexyl) phthalate, benzyl butyl phthalate and di-isodecyl phthalate were higher in males than in females. In addition, mono-2-ethylhexyl phthalate was decreased with age. Our findings suggest that there might be significant demographic variations in exposure and/or metabolism of phthalates, and that health-risk assessment for phthalate exposure in humans should consider different potential risk groups.
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KEYWORD
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Phthalates, Demographics, Risk assessment
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